A seizure is a brain losing control of its own rhythm.
We work on giving it back.
A neuropharmacology research group at KNUST, Kumasi, working from Ghanaian medicinal plants through to the health systems that deliver medicines.
Why this matters
- 1 in 3
- people with epilepsy keep having seizures on every available medicine
- 1 in 10
- Medicines in low- and middle-income countries are estimated to be substandard or falsified
- 50M+
- People worldwide live with epilepsy
Who we are
We investigate how brain function breaks down in disease and how it can be restored — identifying bioactive compounds from Ghanaian flora, working out how they act, and asking whether the resulting medicines reach the people who need them. That last question drives much of the work. A compound that works is of no use if the medicine never arrives.
What we work on
Drug-resistant epilepsy
Why standard anti-seizure medicines fail in some patients, and what can be done for them.
Compounds from Ghanaian flora
Antiaris toxicaria, Picralima nitida, Xylopia aethiopica — isolation, mechanism, safety.
The gut–brain axis
Microbial communities, short-chain fatty acids, and how the gut shapes seizure threshold.
Neuroinflammation
Inflammatory signalling and demyelination as drivers of chronic neurological disease.
Medicines systems and access
Supply chains, traceability and claims data — whether medicines reach patients.
Latest
Gut dysbiosis in people with epilepsy: a dual-site cross-sectional study of Enterobacteriaceae patterns and clinical correlates in peri-urban and urban Ghana
Aqueous extract of Antiaris toxicaria alleviates LPS-induced neuroinflammation by modulating NF-κB signalling
Antidepressant-like effect of Picralima nitida total crude alkaloidal fraction in mice
Join us
We take postgraduate students and interns every year
If your interests overlap with ours, read a couple of our recent papers and tell us which questions interest you and why.